Deconvolution using pre-normalized count matrix and pre-calculated basis matrix.
deconv_simple( count.filter.norm, basis.norm, iter.max = 2000, nu = 1e-10, epsilon = 0.001, truep = NULL )
| count.filter.norm | Normalized count matrix for bulk samples. Genes by samples. |
|---|---|
| basis.norm | Basis matrix calculated from single cell samples. Genes by cell-types. |
| iter.max | the maximum number of iteration in WNNLS |
| nu | a small constant to facilitate the calculation of variance |
| epsilon | a small constant number used for convergence criteria |
| truep | true cell-type proportions for bulk samples if known |
Estimated proportion-prop.est.mvw for bulk samples